This metabolite has a PDE selectivity profile much like sildenafil and an in vitro potency for PDE5 roughly fifty% with the parent drug. Plasma concentrations of the metabolite are somewhere around forty% of People observed for sildenafil, so the metabolite accounts for about 20% of sildenafil's pharmacologic effects.
are allergic to sildenafil, as contained in VIAGRA and REVATIO, or any from the substances in VIAGRA. See the finish of this leaflet for an entire list of elements in VIAGRA.
Due to the fact medical trials are performed beneath extensively different circumstances, adverse response rates observed within the scientific trials of the drug can not be immediately as compared to costs in the medical trials of Yet another drug and will not reflect the fees observed in clinical apply.
Sildenafil is additionally sometimes employed to treat pulmonary hypertension (substantial hypertension during the blood vessels that offer the lungs).
This Investigation was done retrospectively, and was not run to detect any pre-specified difference in adverse reactions.
Snakk med lege før du tar legemidlet dersom du har høyt blodtrykk som ikke er godt behandlet eller uregelmessige hjerteslag/hjertebank. Les pakningen og pakningsvedlegget nøye før bruk.
Seksuell aktivitet kan være ekstra belastende for hjertet. Dersom du har hjerteproblemer eller tror du kan ha et hjerteproblem er det viktig at du opplyser om dette i samtalen med farmasøyten i apotek. Du bør ta en helsesjekk hos din fastlege så snart som mulig i løpet av de fileørste six månedene etter du har begynt å bruke Viagra Reseptfri.
Using VIAGRA features no security in opposition to sexually transmitted disorders. Counseling of clients in regards to the protective actions required to guard against sexually transmitted illnesses, such as the Human Immunodeficiency Virus (HIV), may very well be thought of.
People that have endured a myocardial infarction, stroke, or life-threatening arrhythmia inside the final six months;
Necessarily mean sildenafil plasma concentrations measured after the administration of only one oral dose of a hundred mg to healthful male volunteers is depicted underneath:
The concomitant administration of the protease inhibitor ritonavir considerably boosts serum concentrations of sildenafil (eleven-fold increase in AUC). If VIAGRA is prescribed to patients getting ritonavir, caution need to be employed. Info from topics subjected to significant systemic levels of sildenafil are restricted.
Acetildenafil and other artificial structural analogs of sildenafil which can be PDE5 inhibitors are already uncovered as adulterants in a variety of "herbal" aphrodisiac products bought above-the-counter.[41] These analogs haven't gone through any of the rigorous testing that medicine like sildenafil have handed, and thus have unknown aspect-influence profiles.
While there have been no serious adverse activities possibly related to blood pressure level reported With this research, click here a person topic described average vasodilatation soon after both VIAGRA 50 mg and 100 mg. There were no episodes of syncope described During this analyze.
Dette fordi potenspillen kan påvirke effekten av enkelte andre medikamenter, spesielt de som lindrer brystsmerter. Du skal ikke bruke en slik impotens behandling dersom du: